ТР53 Codon 72 Polymorphism and Human Papilloma Virus-Associated Cervical Cancer in Kyrgyz Women
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چکیده
منابع مشابه
p53 codon 72 polymorphism and human papillomavirus associated skin cancer.
BACKGROUND/AIMS Non-melanoma skin cancers frequently harbour multiple human papillomavirus (HPV) types. A recent report suggests that a polymorphism of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at position 72 of the p53 protein might act as a risk factor in HPV associated malignancies. This study aimed to determine the followin...
متن کاملp53 codon 72 polymorphism in cervical cancer patients and healthy women from Poland.
A polymorphism at codon 72 of gene p53 results in the presence of either arginine or proline at this position. We investigated the distribution of p53 codon 72 polymorphism in cervical cancer patients and a control group of healthy women from Poland. Our results do not confirm the hypothesis that the p53 codon polymorphism could play a role as a factor for squamous carcinoma of the cervix.
متن کاملHuman papilloma virus and cervical cancer.
From epidemiological viewpoint, it has been elucidated that cervical cancer is caused by something transmitted through sexual contact. At present, human papilloma virus, HPV, is thought to be one of the most important candidates, because 60-80% of invasive cancer as well as 30-50% of premalignant lesions of the cervix contain HPV, most of which is HPV-16 or 18. However, these HPVs are detected ...
متن کاملPrevalence Of Human Papilloma Virus Among Women With Cervical Intraepithelial Neoplasia III And Invasive Cervical Cancer From 2001 To 2006 In Bandarabas
Background and Objective: To estimate the risk of human papilloma virus (HPV) infection for cervical malignancies, we conducted a case-control study in southern Iran (Hormozgan province). Materials and Methods: For this purpose,52 paraffin embedded blocks with exact diagnosis of cervical carcinoma(50 carcinomas and 2 carcinomas in situ) from 2001 to 2006 and 52 praffin embedded blocks of ce...
متن کاملp53 codon 72 polymorphism and risk of cervical carcinoma in Korean women.
A common polymorphism of the wild type p53 is known at codon 72 of exon 4, with 2 alleles encoding either arginine (CGC, p53Arg) or proline (CCC, p53Pro). A recent study suggested that this polymorphism affects the susceptibility of p53 protein to human papillomavirus E6 oncoprotein mediated degradation and that individuals homozygous for p53Arg are seven times more susceptible to HPV-associate...
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ژورنال
عنوان ژورنال: Asian Pacific Journal of Cancer Prevention
سال: 2019
ISSN: 2476-762X
DOI: 10.31557/apjcp.2019.20.4.1057